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Natural simian foamy virus infection in wild-caught gorillas, mandrills and drills from Cameroon and Gabon

¹ Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département EMMI, Institut Pasteur, Paris, France
² Centre Pasteur du Cameroon, Yaoundé, Cameroon
³ Centre International de Recherches Médicales, Franceville, Gabon
⁴ CNRS UPR 9051, Hôpital Saint Louis, Paris, France

Correspondence
Antoine Gessain
agessain{at}pasteur.fr

A survey for the presence of simian foamy retroviruses (SFVs) was performed in 44 wild-caught apes and monkeys, including 27 gorillas, 11 mandrills and six drills, originating from south Cameroon or Gabon. Combined serological and/or nested-PCR assays indicated SFV infection among five Gorilla gorilla gorilla, seven Mandrillus sphinx and two Mandrillus leucophaeus. Sequences of a 425 bp fragment of the integrase gene were obtained for 11 animals. Phylogenetic studies indicated that strains from gorillas, mandrills and drills each formed a highly supported phylogenetic clade with, moreover, the existence of two different gorilla SFVs. This study demonstrates for the first time that these animals are naturally infected with specific SFVs. In the context of simian-to-human interspecies transmission, the results confirm that such viruses can also infect humans, as the SFVs identified in wild-caught animals were the same as those recently reported as infecting hunters living in the same geographical areas.

The GenBank/EMBL/DDBJ accession numbers of the 11 novel SFV strains determined in this work are AY583775–AY583782 and AY603409–AY603411.

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